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Stavzor

Patient pill swallowing preferences

For many people, swallowing pills, tablets or capsules is a challenge that may prevent them from adhering to recommended therapy.

A patient survey supports patient preference for small, easy-to-swallow soft gel capsules. STAVZOR soft gel capsules are up to 40% smaller than Depakote® or Depakote ER® (divalproex sodium)* tablets (500 mg dosage formulation).

Pill swallowing difficulty

Noncompliance is a particular concern for patients with chronic neurologic disorders.

Many people have difficulty swallowing pills, according to a survey of swallowing difficulty with oral medications in adults in the United States:

  • Forty percent of individuals who have taken oral medication reported difficulty in swallowing pills.
  • Eighty-four percent reported they hesitate taking medication due to pill size.
  • Fewer than 25% discussed the problem with a healthcare professional.
Study: 84% hesitate taking medication due to pill size. 40% had difficulty swallowing pills.

Study design: Harris Interactive investigators conducted online interviews with 679 adults ages 18 and older. The study population was weighted to ensure a sample representative of the general adult population. The most frequently reported diagnosed conditions were allergies, hypertension, and arthritis. Conditions were generally treated with oral prescription or over-the-counter medications. Survey included 66 questions, some of which were excluded for individual participants based upon response.

Patient preference for soft gel capsules

Clear oval soft gel capsules like STAVZOR help meet patient's needs:

  • When asked to view various dosage forms, 71% (86% female) of consumers preferred clear oval soft gel capsules.
  • A patient survey confirms that 83% of Depakote/Depakote ER* patients would prefer soft gel capsules like STAVZOR as long as it was equal in effectiveness and side effects.
  • 85% of Depakote/Depakote ER patients would have preferred that their physician would have prescribed a soft gel capsule like STAVZOR if it had been available when they started therapy.
comparison of different forms of pills

Adapted from JonesWJ, Francis JJ.
Pills shown were photographed together, then proportionally reduced to fit into the chart. The clear, oval softgel is STAVZOR(valproic acid) Delayed Release Capsules, the oblong compressed tablet is Depakote®. Both were used in the study. Other dosage forms, except the opaque oblong softgel, are OTC products comparable to those used in the study.
Study design: Adults aged 25-60+ examined 8 unidentified dosage forms laid out on a sample board (they were not allowed to ingest any product). They were asked to describe each dosage form, then rank it in terms of ease of swallowing, time to onset, length of action, and other criteria. Respondents could choose more than one dosage form. Results for ease of swallowing are shown in column 2. Overall result across all criteria is shown in column 3.

Help your patients save money on their small, easy-to-swallow STAVZOR soft gel capsules. The STAVZOR Easy Save Pharmacy Card will save up to $50 on every STAVZOR prescription. (Certain restrictions apply.) Direct your patients to sign up to receive their free STAVZOR co-pay benefits cards.

*Depatoke/Depakote ER (divalproex sodium) are registered trademarks of Abbott Laboratories, North Chicago, IL.

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Important Safety Information You Should Know about STAVZOR

Liver problems Your doctor should check your liver function before you start taking STAVZOR and at frequent intervals while you're on therapy. If you feel generally ill (malaise), weak, and tired, if your face is swollen and you lose your appetite, and start vomiting, call your doctor immediately.

Pregnancy: Birth defectsWomen who can become pregnant need to know that valproic acid has been associated with birth defects, in particular with spina bifida, a condition in which the baby's spinal canal fails to close. If you are planning to become pregnant, you should discuss the risks of birth defects, along with other possible treatment options, with your doctor. If you do become pregnant while taking STAVZOR, call your doctor immediately.
Read more important safety information about pregnancy.

PancreatitisSome people taking valproate have experienced a serious, life-threatening illness called pancreatitis (inflamed pancreas). If you experience stomach pain, nausea, vomiting, and/or loss of appetite, call your doctor immediately.

Common side effects reported in studies with valproate were nausea, drowsiness, vomiting, and dizziness. These are not all the side effects that may occur. You will find a complete list of side effects in the full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


Recent Information about Antiepileptic Medications including STAVZOR® (valproic acid) Delayed Release Capsules for any use

For Patients and Caregivers

All antiepileptic medicines, used for any condition, may increase suicidal thoughts or actions in some patients. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.

Watch for and call the healthcare provider right away to report if you or your family member see the appearance or worsening of symptoms of depression, any unusual changes in mood or behavior, or the appearance of suicidal thoughts, behavior, or thoughts about self-harm. Behaviors of concern should be reported immediately to the healthcare provider.

For Healthcare Professionals

All antiepileptic drugs (AEDs), including STAVZOR, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Anyone considering prescribing Stavzor or any other AED must balance their risk of suicidal thoughts and behavior with the risk of untreated illness.

Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior or thoughts about self-harm. Behaviors of concern should be reported immediately to healthcare providers.

For medical inquiries specific to Stavzor, please call 1-800-455-8070